Association of type 2 diabetes with osteoporosis and fracture risk: A systematic review and meta-analysis.

ABSTRACT:

Background

Osteoporosis, a systemic skeletal disease characterized by low bone mass and increased fracture risk, poses significant social and economic challenges globally, while type 2 diabetes mellitus (T2DM), a prevalent metabolic disorder, has been linked to complex effects on bone health, including contradictory findings on its relationship with osteoporosis and fracture risk.

Methods

We searched PubMed, Embase, Cochrane, and Web of Science Library to identify observational studies investigating whether people with T2DM have a higher risk of osteoporosis or fracture than people without diabetes. The time limit for literature retrieval was from the establishment of the database until March 2023. The quality of the studies was assessed using the Newcastle-Ottawa Scale and

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11813021 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature