Causal association of metformin treatment with diverse immune-mediated inflammatory diseases: A Mendelian randomization analysis.

ABSTRACT: Metformin has been shown to possess immune-modulating and anti-inflammatory effects in various animal and clinical studies. It is believed to be effective in treating some immune-mediated inflammatory diseases (IMIDs). However, there remains ongoing debate regarding the extent to which metformin can reduce the risk of developing IMIDs. We used the data from genome-wide association studies to explore the causal relationship between metformin treatment and some IMIDs through the Mendelian randomization (MR) analysis. Additionally, sensitivity analyses were performed using the Cochran Q-test, MR-PRESSO and "leave-one-out" to confirm the robustness of our conclusions. The MR analysis indicated that metformin treatment could reduce the risk of rheumatoid arthritis (RA) (OR = 0.018, 95% CI: 1.33

SUBMITTER: Liao Z 

PROVIDER: S-EPMC11813035 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature