Severe outcomes of COVID-19 among adults with increased risk conditions: A population-based observational study.

ABSTRACT:

Background

The individual risk of severe outcomes following COVID-19 is poorly understood in populations with prior immunity. The lack of contemporary estimates limits support of timely diagnosis and antiviral treatment for individuals most likely to benefit.

Objective

To determine the risk of severe outcomes following COVID-19 within strata of comorbidities, including patients without documented infection.

Design

Population-based cohort study utilizing electronic medical records and g methods to account for selection bias in the documentation of COVID-19 illnesses.

Setting

A large health system in northeastern United States.

Patients

Adults with increased risk conditions (90% vaccinated) and COVID-19 from June to December 2022.

Measurements

Incid

SUBMITTER: Dryden-Peterson S 

PROVIDER: S-EPMC11813104 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature