Single-unit activity in the anterior claustrum during memory retrieval after trace fear conditioning.

ABSTRACT: We have recently identified a group of claustral neurons that continuously maintain information associated with a fear-conditioned stimulus (CS) for at least tens of seconds, even after the CS has ceased. This "online state" refers to the persistent maintenance of threat-associated information, enabling it to be actively processed even after the threat has terminated. This state may involve reciprocal interactions of the claustral neurons with brain regions involved in decision-making, motor preparation, and adaptive behavioral responses. If these claustral neurons truly encode the online state, their function should remain independent of the modality of the threat stimulus or the specific defensive behavior exhibited. In this study, we used a tone cue and monitored freezing behavior in tr

SUBMITTER: Park S 

PROVIDER: S-EPMC11813112 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature