PRC2 promotes canalisation during endodermal differentiation.

ABSTRACT: The genetic circuitry that encodes the developmental programme of mammals is regulated by transcription factors and chromatin modifiers. During early gestation, the three embryonic germ layers are established in a process termed gastrulation. The impact of deleterious mutations in chromatin modifiers such as the polycomb proteins manifests during gastrulation, leading to early developmental failure and lethality in mouse models. Embryonic stem cells have provided key insights into the molecular function of polycomb proteins, but it is impossible to fully appreciate the role of these epigenetic factors in development, or how development is perturbed due to their deficiency, in the steady-state. To address this, we have employed a tractable embryonic stem cell differentiation system to model

SUBMITTER: Holzenspies JJ 

PROVIDER: S-EPMC11813121 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature