High mean corpuscular volume as a predictor of esophageal cancer: A cohort study based on the Japanese Shizuoka Kokuho Database.

ABSTRACT: Mean corpuscular volume (MCV) is known to increase with alcohol and tobacco consumption, and is therefore a potential predictive marker for esophageal cancer onset. However, this potential has not previously been examined using a large database. This study aims to clarify whether MCV is a predictor of esophageal cancer onset using health checkup data from a comprehensive health insurance claims database of a major administrative district in Japan. Health checkup data for 582,342 individuals recorded between April 2012 and September 2020 in the Shizuoka Kokuho Database were analyzed. Risk factors were assessed using both univariable and multivariable Cox proportional hazards models. Within the cohort, 1,562 health checkup participants (0.27%) had been diagnosed with esophageal cancer during

SUBMITTER: Sato S 

PROVIDER: S-EPMC11813134 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature