Network study of miRNA regulating traumatic heterotopic ossification.

ABSTRACT:

Objective

Objective: To identify and analyze the microRNAs that are expressed differently (DE-miRNAs) and forecast their potential roles in the pathophysiological process of traumatic heterotopic ossification (THO).

Methods

We conducted RNA sequencing on six samples of normal bone and THO tissues from the patients and conducted differential expression analysis of miRNA. The biological activities of the target genes of the differentially expressed microRNAs (DE-miRNAs) were investigated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The miRNA-mRNA network was constructed using Cytoscape software, incorporating miRNAs with varying expression levels and their corresponding target genes.

Results

In comparison to the normal control gr

SUBMITTER: Lian K 

PROVIDER: S-EPMC11813146 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature