Mendelian randomization analysis to identify potential drug targets for osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a prevalent chronic joint disease for which there is a lack of effective treatments. In this study, we used Mendelian randomization analysis to identify circulating proteins that are causally associated with OA-related traits, providing important insights into potential drug targets for OA.

Method

Causal associations between 1553 circulating proteins and five OA-related traits were assessed in large-scale two-sample MR analyses using Wald ratio or inverse variance weighting, and the results were corrected for Bonferroni. In addition, sensitivity analyses were performed to validate the reliability of the MR results, including reverse MR analysis and Steiger filtering to ensure the causal direction between circulating proteins and OA; Bayesian

SUBMITTER: Lu C 

PROVIDER: S-EPMC11813149 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature