Macro- and micro-scale culture environment differentially regulate the effects of crowding on macrophage function.

ABSTRACT: Macrophages hold vital roles in immune defense, wound healing, and tissue homeostasis, and have the exquisite ability to sense and respond to dynamically changing cues in their microenvironment. Much of our understanding of their behavior has been derived from studies performed using in vitro culture systems, in which the cell environment can be precisely controlled. Recent advances in miniaturized culture platforms also offer the ability to recapitulate some features of the in vivo environment and analyze cellular responses at the single-cell level. Since macrophages are sensitive to their surrounding environments, the specific conditions in both macro- and micro-scale cultures likely contribute to observed responses. In this study, we investigate how the presence of neighboring cells inf

SUBMITTER: Hsu SJ 

PROVIDER: S-EPMC11813229 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature