Predicting Mesoscopic Larmor Frequency Shifts in White Matter With Diffusion MRI-A Monte Carlo Study in Axonal Phantoms.

ABSTRACT: Magnetic susceptibility MRI offers potential insights into the chemical composition and microstructural organization of tissue. However, estimating magnetic susceptibility in white matter is challenging due to anisotropic subvoxel Larmor frequency shifts caused by axonal microstructure relative to the B0 field orientation. Recent biophysical models have analytically described how axonal microstructure influences the Larmor frequency shifts, relating these shifts to a mesoscopically averaged magnetic field that depends on the axons' fiber orientation distribution function (fODF), typically estimated using diffusion MRI. This study is aimed at validating the use of MRI to estimate mesoscopic magnetic fields and determining whether diffusion MRI can faithfully estimate the orientation depende

SUBMITTER: Sandgaard AD 

PROVIDER: S-EPMC11813543 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature