Effects of <i>n</i>-3 very-long-chain PUFA on bone mineralisation.

ABSTRACT: The present study investigated whether dietary n-3 very-long-chain PUFA (n-3 VLC-PUFA) could increase skin and bone mineralisation in Atlantic salmon (Salmo salar) in vivo and examined their potential effects on human osteoblast proliferation and differentiation in vitro. Atlantic salmon were fed different dietary levels of n-3 VLC-PUFA, and changes in tissue n-3 VLC-PUFA composition, skeletal morphology, skin and bone mineral content, bone mineral density (BMD) and gene expression patterns were examined. Additionally, in vitro experiments using human foetal osteoblast cells were conducted to investigate the potential influence of n-3 VLC-PUFA supplementation on cell proliferation, osteogenic differentiation and cytokine expres

SUBMITTER: Torrissen M 

PROVIDER: S-EPMC11813626 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature