Chirooptical 2,2'-Dimethoxybiphenyl Crystals Generated From Suzuki-Miyaura Coupling Reaction Catalyzed by Pd-Loaded Chiral Silica.

ABSTRACT: In this work, we report a one-pot approach that combines crystal ripening with the Suzuki-Miyaura coupling reaction. We investigated the reaction between 2-methoxyphenyl bromide and 2-methoxyphenylboronic acid, catalyzed by a series of Pd-loaded chiral optical (_D- or _L-) and racemic (_DL-) silica/polyethyleneimine (PEI) systems, which produced crystalline 2,2'-dimethoxybiphenyl (DMB). The silica used as a catalyst was prepared using our previously established method, in which chirality was imparted to the silica through catalytic templates composed of polyethyleneimine (PEI) and tartaric acid. Both enantiopure (_D- or _L-; 100% ee) and racemic (_DL-; 0% ee) tartaric acid-mediated silica, after tartaric acid removal and palladium

SUBMITTER: Yoshimori S 

PROVIDER: S-EPMC11813723 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature