Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulated <i>C. acnes-</i>treated SZ95 sebocytes.

ABSTRACT:

Background

Afzelin, a flavonoid (kaempferol 3-O-α-L-rhamnopyranoside) isolated from Thesium chinense, is known for its potent anti-inflammatory properties. However, its effects on the molecular aspects of inflammation and lipogenesis in SZ95 sebocytes has not been investigated.

Objective

This study aimed to (i) investigate inflammatory and sebum secretion changes when a Cutibacterium acnes-treated immortalized human sebocyte cell line (SZ95) is exposed to particulate matter (PM) and (ii) examine the effects of afzelin on these.

Methods

To investigate the effect of afzelin on PM- and C. acnes-treated SZ95 sebocytes, we injected heat-killed C. acnes into SZ95 cells to induce acne-like status. Thereafter, the SZ95 sebocytes were treated with P

SUBMITTER: Hong JY 

PROVIDER: S-EPMC11813740 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature