Efficacy and safety of pseudolaric acid B against <i>Echinococcus multilocularis in vitro</i> and in a murine infection model.

ABSTRACT:

Introduction

Alveolar echinococcosis (AE) is a chronic zoonotic disease caused by the larvae of the Echinococcus multilocularis (E. multilocularis). The current chemotherapy for AE relies on albendazole and mebendazole, which exhibit only parasitostatic rather than parasiticidal effects. Therefore, there is a need to find new anti-Echinococcosis drugs. Pseudolaric acid B (PAB) has been described to have strong antiparasitic effects. However, the in-depth mechanism by which PAB acts against E. multilocularis remains unclear.

Methods

To evaluate the effect of a PAB intervention on protoscoleces, metacestode vesicles and germinal cells in E. multilocularis in vitro. In addition, the effects of PAB on T lymphocyte and collagen synthesis were evaluated

SUBMITTER: Dawa ZM 

PROVIDER: S-EPMC11813755 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature