Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis.

ABSTRACT:

Purpose

The purpose of this current study was to find out whether human immunodeficiency virus (HIV) affected overall survival (OS) of colorectal cancer (CRC) patients after surgery.

Methods

PubMed, Embase, the Cochrane Library, and CNKI were searched from inception to March 27, 2023 to find eligible studies. Eligible studies included CRC patients grouped by HIV status (HIV-positive and HIV-negative). Stata SE 16 was used for data analysis.

Results

A total of eight studies involving 2180 patients were enrolled in this study. After data analysis, there were significant differences in sex (OR=0.69, 95% CI=0.49 to 0.98, I² = 22.6%, P=0.04<0.1), tumor grade (OR=6.61, 95% CI=2.36 to 18.49, I² = 0.00%, P=0.00<0.1), and tumor location (OR=2.19, 95% CI=1

SUBMITTER: Yang WW 

PROVIDER: S-EPMC11813759 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature