Transcriptome profiling revealed multiple circadian rhythm-related genes associated with common gynecological cancers.

ABSTRACT:

Background

Studies have shown that more than half of the human genome expression is affected by circadian rhythms, which includes genes involved in cell cycle control, DNA repair and apoptosis that are critical in cancer biology. However, the roles of circadian rhythm-related genes (CRRGs) in cervical cancer (CC) and other common gynecologic cancers remain unclear.

Methods

The transcriptome data and clinical information related to CC and other common gynecologic cancers were extracted from the UCSC Xena and Gene Expression Omnibus (GEO) databases. In this study, the differentially expressed CRRGs of CC (target genes) were obtained, and the functional enrichment analysis of these target genes was performed by "clusterProfiler". Then, the biomarkers of CC were screened out to

SUBMITTER: Peng L 

PROVIDER: S-EPMC11813765 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature