Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study.

ABSTRACT:

Objective

The aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.

Methods

Based on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed two-sample bidirectional MR analyses using single nucleotide polymorphisms (SNPs) as instrumental variables. We used inverse variance weighting (IVW), weighted median, weighted mode, and MR-Egger to assess bidirectional causality between sex hormones and IBD.

Results

There was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation bet

SUBMITTER: Wang K 

PROVIDER: S-EPMC11813775 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature