Cellular and immune landscape of chronic liver diseases: insights from immunophenotyping.

ABSTRACT:

Background

Chronic liver disease due to alcohol-related liver disease and chronic viral hepatitis pose a substantial burden on healthcare systems. Chronic liver disease may predispose to hepatocellular carcinoma, for which therapeutic options are limited. This study aimed to explore the immune cell characteristics of the clinical conditions.

Methods

Explant liver samples were collected from 25 patients for bulk RNA sequencing and flow cytometry analysis. Immune cell populations were characterized by flow cytometry from isolated hepatic and peripheral mononuclear cells.

Results

Significant differences in immune cell characteristics were observed among patients with three clinical conditions. Viral hepatitis and peri-tumor samples exhibited higher hepatic B cell counts

SUBMITTER: Soleimani S 

PROVIDER: S-EPMC11813787 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature