Altered Self-Referential-Related Brain Regions in Depersonalization-Derealization Disorder.

ABSTRACT:

Objective

We aimed to explore the alteration in topology and network properties in self-referential-related brain regions of individuals with depersonalization-derealization disorders (DPD), using evidence from resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

We first determined the regions of interest (ROIs) using Neurosynth, based on which we conducted an ROI-wise functional connectivity search to create a self-referential-related network and performed a topographical analysis. We then compared the analyzed properties from the rs-fMRI of disordered individuals to those of healthy controls to generate differential properties, based on which we conducted a machine learning-based disease diagnostic model.

Results

The study found significant change

SUBMITTER: Jia Y 

PROVIDER: S-EPMC11813808 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature