Neutrophil-induced pyroptosis promotes survival in patients with hepatoblastoma.

ABSTRACT:

Background

Hepatoblastoma (HB) is the predominant hepatic malignancy among children. Despite therapeutic options for HB were gradually refined in recent years, patients with metastasis suffer from an unsatisfactory prognosis. Pyroptosis is a type of programmed and inflammatory necrosis. Neutrophils are crucial in innate immunity, which were shown to be associated with tumor progression. Our study strived to unravel the relationship between neutrophil-induced pyroptosis (NIP) and HB.

Methods

The clinical and bulk RNA sequencing data of 38 patients with HB were obtained from Shanghai Children's Medical Center. We established NIP score based on the LASSO regression. The single-cell RNA sequencing data (GSE186975) were used for for key genes identification, cellular communicatio

SUBMITTER: Fu T 

PROVIDER: S-EPMC11813845 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature