Activity of silver-zinc nanozeolite-based antibiofilm wound dressings in an in vitro biofilm model and comparison with commercial dressings.

ABSTRACT:

Background

Infected wounds are a major health problem as infection can delay wound healing. Wound dressings play an important part in wound care by maintaining a suitable environment that promotes healing. Silver sulfadiazine dressings have been used to prevent infection in burn wounds. Presently, many commercial silver dressings have obtained FDA clearance.

Results

In this study, we report on a novel silver dressing using microporous aluminosilicate zeolites, termed ABF-XenoMEM. Silver and zinc ions are encapsulated in the zeolite supercages. We show that the silver-zinc zeolite (AM30) alone is effective at inhibiting biofilm formation. The encapsulation protects the silver from rapidly precipitating in biological fluids. We exploit the negatively charged zeolite surface to

SUBMITTER: Alobaid SA 

PROVIDER: S-EPMC11813856 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature