Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m.

ABSTRACT:

Introduction

Acute mountain sickness (AMS) is a common altitude illness that occurs when individuals rapidly ascend to altitudes ≥2,500 m without proper acclimatization. Genetic and genomic factors can contribute to the development of AMS or predispose individuals to susceptibility. This study aimed to investigate differential gene regulation and biological pathways to diagnose AMS from high-altitude (HA; 4,300 m) blood samples and predict AMS-susceptible (AMS+) and AMS-resistant (AMS─) individuals from sea-level (SL; 50 m) blood samples.

Methods

Two independent cohorts were used to ensure the robustness of the findings. Blood samples were collected from participants at SL and HA. RNA sequencing was employed to profile gene expression. Differential expression analysis and pa

SUBMITTER: Yang R 

PROVIDER: S-EPMC11813865 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature