Radiomics-based biomarker for PD-1 status and prognosis analysis in patients with HCC.

ABSTRACT:

Purpose

To investigate the impact of preoperative contrast-enhanced CT-based radiomics model on PD-1 prediction in hepatocellular carcinoma (HCC) patients.

Methods

The study included 105 HCC patients (training cohort: 72; validation cohort: 33) who underwent preoperative contrast-enhanced CT and received systemic sorafenib treatment after surgery. Radiomics score was built for each patient and was integrated with independent clinic radiologic predictors into the radiomics model using multivariable logistic regression analysis.

Results

Seventeen radiomics features were finally selected to construct the radiomics score. In multivariate analysis, serum creatine and peritumoral enhancement were significant independent factors for PD-1 prediction. The radiomics model integ

SUBMITTER: Hapaer G 

PROVIDER: S-EPMC11813882 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature