Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents.

ABSTRACT:

Introduction

The multi-targeted ligands (MTDL) strategy has been recognized as a promising Approach for the development of effective treatments against Alzheimer's disease (AD), due to the presence of multiple pathological mechanisms in AD. In this study, a series of bis(7)-harmine derivatives were designed and synthesized as multifunctional drugs for the treatment of AD.

Methods

The derivatives were synthesized by chemical methods and their structure was confirmed by nuclear magnetic resonance (NMR). The Ellman's assay was utilized to assess the inhibitory potential of derivatives against hAChE and hBuChE. The inhibitory activity of these derivatives on both hMAO-A and hMAO-B was assessed using a fluorescence-based method. The thioflavin T (Th-T)

SUBMITTER: Du H 

PROVIDER: S-EPMC11813896 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature