Recalibrating the kidney failure risk equation for a Mediterranean European population: reducing age and sex inequality.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) patients may develop kidney failure (KF), receiving renal replacement therapy (RRT) in some cases. The Kidney Failure Risk Equation (KFRE-4), predicting RRT risk, is widely validated but not in a primary care Mediterranean European population. We aim to recalibrate KFRE-4 accordingly, considering death as a competing risk, to improve performance. Additionally, we recalibrate KFRE-4 for predicting KF, including all patients reaching CKD stage 5, not just those on RRT.

Methods

Retrospective cohort study including individuals aged ≥50 years with confirmed glomerular filtration rate (eGFR) <60 mL/min/1.73m² and measured albumin-to-creatinine ratio (ACR). Dataset was split into training and test sets. New KFRE-4 models were dev

SUBMITTER: Bundo-Luque D 

PROVIDER: S-EPMC11813909 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature