Population dynamics analysis of the interaction between tacrolimus and voriconazole in renal transplant recipients.

ABSTRACT:

Background

The concurrent administration of tacrolimus and voriconazole in kidney transplant recipients can lead to drug interactions, potentially resulting in severe adverse reactions. This study aimed to establish a robust population pharmacokinetic model to explore the interaction between tacrolimus and voriconazole in greater depth.

Methods

Tacrolimus blood samples and laboratory data were prospectively collected from eligible patients enrolled between April 2023 and April 2024, following predefined inclusion and exclusion criteria. Using Phoenix (version 8.1), a pharmacokinetic prediction model was developed. Model performance was assessed using model fitting plots, bootstrap analysis, and visual predictive checks (VPC).

Results

This study ultimately included 51

SUBMITTER: Sun ZH 

PROVIDER: S-EPMC11813913 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature