Carboplatin-resistance-related DNA damage repair prognostic gene signature and its association with immune infiltration in breast cancer.

ABSTRACT:

Introduction

Breast cancer is among the most prevalent malignant tumors globally, with carboplatin serving as a standard treatment option. However, resistance often compromises its efficacy. DNA damage repair (DDR) pathways are crucial in determining responses to treatment and are also associated with immune infiltration. This study aimed to identify the DDR genes involved in carboplatin resistance and to elucidate their effects on prognosis, immune infiltration, and drug sensitivity in breast cancer patients.

Methods

A 3D-culture model resistant to carboplatin was constructed and sequenced. Co-expressed DDR genes were analyzed to develop a predictive model. Immune infiltration analysis tools were employed to assess the immune microenvironment of patients with varying expres

SUBMITTER: Dong S 

PROVIDER: S-EPMC11813922 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature