<i>Bifidobacterium animalis</i> subsp. <i>lactis</i> TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota.

ABSTRACT:

Introduction

Constipation is a common gastrointestinal disorder that can affect quality of life. Probiotics have garnered substantial attention for their potential to alleviate constipation. This study investigates the preventive effects of Bifidobacterium animalis subsp. lactis TG11 on loperamide-induced constipation in mice.

Methods

Mice were randomly assigned to normal control (NC), constipation model (CM), and low, medium, and high-dose TG11 treatment groups (LG, MG, HG). From days 1-14, LG, MG, and HG groups received 10⁶, 10⁷, and 10⁸ CFU/mouse of TG11, respectively, while NC and CM groups received saline. On day 14, all groups except NC were administered loperamide (4 mg/kg) orally to induce constipation. Fecal samples wer

SUBMITTER: Ma W 

PROVIDER: S-EPMC11813947 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature