New approach to busulfan dosing in infants and children based on a population pharmacokinetic analysis.

ABSTRACT:

Purpose

Apply population pharmacokinetic modeling to a single institution busulfan therapeutic drug monitoring (TDM) data set from infants and children to refine dosing methods.

Methods

One-compartment pharmacokinetic model was fit to busulfan TDM data from 328 infants and children with malignant and non-malignant diseases treated with busulfan-containing transplant conditioning regimens. Age-dependence of busulfan clearance scaled to body weight and body surface area (BSA) was compared, and busulfan AUC was simulated for a BSA-scaled dose of 100 mg/m² combined with a BSA-banded dosing table for infants and children with a BSA < 0.5 m².

Results

Busulfan clearance scaled to body weight is age-dependent. Clearance in children ≤ 3 years (0.234 L/[h•

SUBMITTER: Balis FM 

PROVIDER: S-EPMC11813957 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature