Visual cortical activity in Charles Bonnet syndrome: testing the deafferentation hypothesis.

ABSTRACT: Visual hallucinations in individuals following sight loss (Charles Bonnet syndrome; CBS) have been posited to arise because of spontaneous, compensatory, neural activity in the visual cortex following sensory input loss from the eyes-known as deafferentation. However, neurophysiological investigations of CBS remain limited. We performed a multi-modal investigation comparing visual cortical activity in 19 people with eye disease who experience visual hallucinations (CBS) with 18 people with eye disease without hallucinations (ED-Controls; matched for age and visual acuity) utilising functional MRI, EEG, and transcranial magnetic stimulation (TMS). A pattern of altered visual cortical activity in people with CBS was noted across investigations. Reduced BOLD activation in ventral extrastriate

SUBMITTER: daSilva Morgan K 

PROVIDER: S-EPMC11813974 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature