Omalizumab Treated Urticaria Patients Display T Cell and Thrombocyte-Associated Gene Regulation.

ABSTRACT:

Background

Chronic spontaneous urticaria (CSU) is a debilitating inflammatory skin disease with a prevalence of approximately 1% of the population. It is characterized by recurrent itchy wheals and/or angioedema for more than 6 weeks without known triggers leading to a high quality of life impairment. The pathogenesis of CSU remains not fully understood.

Objective

This study aimed to explore the pathomechanism of CSU beyond mast cells and IgE-dependent histamine release and to identify possible biomarkers for the disease and its treatment.

Methods

We investigated a patient cohort in the first month of omalizumab treatment regarding the IgE levels and changes in gene and miRNA expression in peripheral blood. The cohort was divided into responders and nonresponders (dep

SUBMITTER: Smola A 

PROVIDER: S-EPMC11813983 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature