Portable ultra-low-field MRI for progressive multifocal leukoencephalopathy: Case studies, sensitivity, and potential applications.

ABSTRACT:

Background and objective

Progressive multifocal leukoencephalopathy (PML) is a severe, disabling infection caused by JC virus reactivation. PML-related disability complicates the MRI monitoring needed to assess treatment interventions in clinical trial or compassionate use settings. Portable ultra-low-field MRI (pULF-MRI) offers a convenient approach when such frequent imaging is needed. We evaluated the potential utility of pULF-MRI as an adjunctive tool for decreasing the burden of clinical study participation and clinical management in PML.

Methods

We examined paired high-field (HF) and pULF-MRI scans from 11 patients, aged 49 ± 15 years. pULF-MRI images with corresponding HF-MRI were coupled to depict key imaging findings of PML, including three patients with longitudina

SUBMITTER: Okar SV 

PROVIDER: S-EPMC11814002 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature