Innovative application of ceftriaxone as a quorum sensing inhibitor in Pseudomonas aeruginosa.

ABSTRACT: Pseudomonas aeruginosa is a Gram-negative bacterium that has the potential to induce various healthcare-related infections through its array of virulence factors. The control of virulence factor expression is mainly regulated by a communication process among cells called quorum sensing (QS). Blocking QS could be a viable tactic to suppress virulence factors and reduce pathogenicity without impacting bacterial growth. This approach has the potential to significantly decrease the multiple drug resistance emergence. In this study, we explored the impact of ceftriaxone (CRO), which is a commonly used β-lactam antibiotic, and its metal derivatives on the QS system and virulence factors of both standard strains and clinical isolates of P. aeruginosa. The quorum sensing inhibitory (QSI) activity

SUBMITTER: Naga NG 

PROVIDER: S-EPMC11814147 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature