Sleep as a mediator between chronic diseases and depression: a NHANES study (2005-2018).

ABSTRACT:

Objective

This article investigates the relationship between common chronic diseases and depression among US adults and examines the mediating role of sleep in this relationship, using a cross-sectional study to offer recommendations for depression prevention.

Methods

This study analyzed data from 10,710 participants collected from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. Logistic regression, subgroup analysis, restricted cubic spline (RCS) analysis, and mediation analysis were employed to explore the relationship between common chronic diseases and depression, and the mediating role of sleep.

Results

The adjusted model indicated that stroke (OR = 1.712, 95% CI: 1.399, 2.103), heart disease (OR = 1.419, 95% CI: 1.262, 1.598)

SUBMITTER: Tan M 

PROVIDER: S-EPMC11814157 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature