Immunoglobulin M response in largemouth bass (<i>Micropterus salmoides</i>) following ranavirus infection.

ABSTRACT: Immunoglobulin M (IgM) and IgM⁺ B cells are key components of the humoral immune system, providing defense against pathogen invasion. While the role of IgM in the systemic and mucosal immune responses of fish to parasites and bacteria has been partially investigated, its function in viral infections remains underexplored. This study successfully developed a largemouth bass (Micropterus salmoides) model for ranavirus immersion infection. Our findings revealed that viral infection caused significant pathological changes in the gill and head kidney tissues, along with a marked upregulation of adaptive immune gene expression. Interestingly, fish that survived an initial viral infection exhibited minimal mortality and low viral loads in the gill and head kidney tissues when ex

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11814181 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature