Cortical activity during painful and non-painful stimulation over four lower limb body sites: a functional near-infrared spectroscopy study.

ABSTRACT: Functional near-infrared spectroscopy (fNIRS) holds potential utility as a measure of neural correlates of pain. However, most studies have focused on upper limb stimulation, with limited investigation into lower limbs. In this study, we utilized fNIRS to observe brain changes in oxyhemoglobin levels during painful and non-painful electrical stimulation of various lower limb sites (bilateral groins and knees) in 16 healthy participants. Additionally, we explored perceptual responses to painful and non-painful electrical stimulation across these lower limb sites. Our findings showed no significant main effect of stimulation across different body sites on oxyhemoglobin activity. However, the interaction between body sites, stimulation modalities, and brain regions significantly influenced ox

SUBMITTER: Liao J 

PROVIDER: S-EPMC11814190 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature