Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review.

ABSTRACT:

Introduction

Behavioral and Psychological Symptoms of Dementia (BPSD) are common neuropsychiatric manifestations that complicate the clinical course of dementia and impact caregiving. Among these, the Hyperactivity-Impulsivity-Irritiability-Disinhibition-Aggression-Agitation (HIDA) and Psychosis (P) domains are particularly challenging to manage. Despite their prevalence, their underlying mechanisms and neuropathological correlates, remain poorly understood. This systematic review aims to elucidate the neuropathological basis of the HIDA and psychosis domains, exploring whether distinct proteinopathies and neural circuit dysfunctions are associated with these symptoms.

Methods

The review follows PRISMA guidelines, with a systematic search conducted across MEDLINE, CENTRAL, a

SUBMITTER: Negro G 

PROVIDER: S-EPMC11814221 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature