Triamcinolone acetonide and botulinum toxin A for upper eyelid retraction in thyroid-associated ophthalmopathy.

ABSTRACT: To evaluate the therapeutic effect of combining subconjunctival botulinum toxin A (BTX-A) with periorbital triamcinolone acetonide (TA) injections in treating upper eyelid retraction (UER) due to thyroid-associated ophthalmopathy (TAO). Fifty eyes with TAO-related UER were randomized into two groups. Group 1 received TA alone, while group 2 received BTX-A plus TA. Marginal reflex distance (MRD1) and graine sign (GS) were measured at baseline and post-injection intervals. Elevated intraocular pressure incidence was monitored. Group 1 showed significant MRD1 reductions at 1, 3, and 6 months (P < 0.05) and a GS increase at 3 months (P < 0.05). Group 2 exhibited quicker MRD1 reductions at 1 week, 1, 3, and 6 months (P < 0.05) and earlier GS improvements at 1 week, 1, and 3 months (P < 0.05). G

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11814297 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature