Transcriptomic profiles link corticostriatal microarchitecture to genetics of neurodevelopment and neuropsychiatric risks.

ABSTRACT: Many studies on macroscale organization have focused on only the cerebral cortex or striatum, leaving a large gap in the microstructural gradient of corticostriatal covariance. Here, we partitioned the striatum into seven distinct parcels and computed the microstructural covariance between each parcel and the cerebral cortex using T1-weighted/T2-weighted mapping. We found that corticostriatal microstructural covariance exhibited a microstructural gradient along the anterior-posterior axis of the striatum. The patterns of corticostriatal microstructural covariance are linked to geodesic distance and cell type-specific gene expression profiles, revealing a gradually attenuated relationship along the anterior-posterior axis of the striatum. Linking gene expression profile to corticostriatal m

SUBMITTER: Hu S 

PROVIDER: S-EPMC11814317 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature