ZCCHC4 regulates esophageal cancer progression and cisplatin resistance through ROS/c-myc axis.

ABSTRACT: Zinc finger CCHC-type containing 4 (ZCCHC4) is a newly discovered N⁶-methyladenosine (m⁶A) RNA methyltransferase (MTase), which possesses an m⁶A MTase domain and an RNA-binding protein (RBP) Znf domain. Aberrantly expressed ZCCHC4 has been found to be correlated with poor prognosis and chemoresistance in various tumors, such as hepatocellular carcinoma, lung cancer and colorectal cancer. However, the expression and functional analysis of the role of ZCCHC4 in esophageal cancer (ESCA) is still elusive. The expression of ZCCHC4 in esophageal cancer tissues was evaluated by qPT-PCR and western blot. Serum esophageal tumor markers are detected by electrochemiluminescence immunoassay. Relationship between ZCCHC4 expression and pathway enrichment analysis were an

SUBMITTER: Yao L 

PROVIDER: S-EPMC11814405 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature