Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats-potential biological sex-dependent effects.

ABSTRACT:

Introduction

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease resulting from repeated mild traumatic brain injuries (rmTBI). The necessity for diagnosis of CTE, which can so far only be confirmed after post-mortem, is a pressing need. New approaches to early diagnose this disease are crucial to facilitate the translation of novel treatment strategies to the clinic. Several studies have found suitable candidate biomarkers, but the results are not straightforward. As biological sex is suggested to be a major confounding factor, we explored how sex influences behavioural and candidate blood biomarkers during CTE-like progression following experimental rmTBI.

Methods

To induce CTE-like development, we subjected male and female rats to three mTBIs

SUBMITTER: Moraga-Amaro R 

PROVIDER: S-EPMC11814444 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature