Locomotor Response to Novelty: What Does It Tell Us?

ABSTRACT: Individual differences in response strategies may be utilized to identify those at risk for the development of neuropsychiatric disorders such as depression, anxiety, and substance use. One behavioral attribute that has been used to predict later mood disorders and substance use disorders is an organism's predisposition for novelty-seeking, modeled in rodents as increased exploration of novel environments or stimuli. Despite documented correlations of locomotor response to a novel environment and disease-specific tendencies, it remains unclear whether the "response to novelty trait" is stable across time and environments. Adolescence is an important transitional time, associated with vulnerability for neuropsychiatric disorders. Only a few studies have assessed whether variations in novelt

SUBMITTER: Kirschmann EK 

PROVIDER: S-EPMC11814917 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature