Late-onset unexplained seizures are associated with cognitive impairment and lower amygdala volumes.

ABSTRACT: Late-onset epilepsy has been linked with accelerated cognitive decline and a higher risk of dementia. In this study, we sought to characterize the cognitive profile of participants with late-onset unexplained epilepsy and compare their MRI findings to healthy controls, to better understand underlying disease mechanisms. We recruited participants with at least one new-onset unexplained seizure at age 55 or later, without cortical lesions on MRI, within 5 years of the first seizure. We administered a neuropsychological battery to generate Preclinical Alzheimer Cognitive Composite and composite scores for delayed verbal recall, processing speed and executive function. We held a consensus meeting to determine whether the participants fulfilled criteria for mild cognitive impairment. An MRI vol

SUBMITTER: Sarkis RA 

PROVIDER: S-EPMC11815171 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature