Tracer kinetic model detecting heterogeneous blood-brain barrier permeability to water and contrast agent in Alzheimer's disease and dementia with Lewy bodies.

ABSTRACT:

Introduction

Blood-brain barrier (BBB) breakdown is essential in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), whereas the variability in BBB permeability to water and contrast agent is less clear.

Methods

We investigated BBB permeability to water and contrast agent simultaneously using a novel tracer kinetic model for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in 42 AD patients, 22 DLB patients, and 22 healthy controls. All participants underwent clinical, cognitive, and MRI assessments.

Results

AD patients exhibited a significant reduction in the water exchange rates across the BBB, whereas DLB patients showed a significant increase in BBB permeability to contrast agent. Moreover, BBB permeability to both water and contrast agent

SUBMITTER: Xu Z 

PROVIDER: S-EPMC11815205 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature