White matter injury, plasma Alzheimer's disease, and neurodegenerative biomarkers on cognitive decline in community-dwelling older adults: A 10-year longitudinal study.

ABSTRACT:

Introduction

This study aimed to investigate the synergistic impact of white matter injury, Alzheimer's disease, and neurodegenerative pathology on long-term cognitive decline and dementia risk in older adults.

Methods

We included 262 dementia-free participants with baseline and follow-up interviews (2010-2021). At baseline, peak width of skeletonized mean diffusivity (PSMD) was assessed from diffusion tensor imaging. Plasma phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) were measured using a single-molecule immune-array assay. Cognitive function was evaluated using Mini-Mental State Examination (MMSE) and domain-specific cognitive tests.

Results

Participants with high-level PSMD, p-tau217, and NfL showed the fastest decline of MMSE (β = -0.30)

SUBMITTER: Hu Q 

PROVIDER: S-EPMC11815209 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature