Lower estimated glomerular filtration rate relates to cognitive impairment and brain alterations.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is associated with cognitive decline and changes in brain structure. However, their associations remain unclear, particularly the selective vulnerability characteristics that make some brain regions more vulnerable.

Methods

We investigated the baseline association between estimated glomerular filtration rates (eGFR) and cognitive function in 15,897 individuals from the CARTaGENE cohort. We performed vertex-based magnetic resonance imaging (MRI) analyses between eGFR and longitudinal cortical thickness in the 1397 participants who underwent brain MRI after 6 years. Imaging transcriptomics was used to characterize the gene expression and neurodegenerative features associated with this association.

Results

Lower eGFR correlated w

SUBMITTER: Rahayel S 

PROVIDER: S-EPMC11815220 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature