Transcriptome analysis of early- and late-onset Alzheimer's disease in Korean cohorts.

ABSTRACT:

Introduction

The molecular mechanisms underlying early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) remain incompletely understood, particularly in Asian populations.

Methods

RNA-sequencing was carried out on blood samples from 248 participants in the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) and weighted gene co-expression network analysis. Findings were replicated in an independent Korean cohort (N = 275).

Results

DGE analysis identified 18 and 88 dysregulated genes in EOAD and LOAD, respectively. Network analysis identified a LOAD-associated module showing a significant enrichment in pathways related to mitophagy, 5' adenosine monophosphate-activated protein kinase signaling, and ub

SUBMITTER: Han SW 

PROVIDER: S-EPMC11815242 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature