Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort.

ABSTRACT:

Background

Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early cognitive changes. We explored the relationship between neurodegenerative biomarkers and cognition in cognitively normal individuals.

Methods

We remotely deployed 13 computerized Cognitron tasks in 255 Insight 46 participants. We generated amyloid load and positivity, white matter hyperintensity volume (WMHV), whole brain and hippocampal volumes at age 73, plus rates of change over 2 years. We examined the relationship between Cognitron, biomarkers, and standard neuropsychological tests.

Results

Slower response time on a delayed recognition task predicted

SUBMITTER: Giovane MD 

PROVIDER: S-EPMC11815243 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature