Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis.

ABSTRACT: Smoking-related osteoporosis (SROP) is characterized by reduced bone mass, primarily due to the accumulation of tobacco-derived toxins. This study demonstrates the activation of ferroptosis and reactive oxygen species (ROS)-related pathways in the bone marrow mesenchymal stem cells (BMSCs) of SROP mice. Here, we integrated genetic engineering and bone-targeting peptide modification to develop innovative bone-targeting engineered exosomes. Using genetic engineering techniques, we introduced α-1,3-fucosyltransferase 6 (Fut6), a key protein involved in prostate cancer bone metastasis, and identified exosomes expressing Fut6 (F6-exo) with bone-targeting capabilities. Additionally, we modified these exosomes with a bone-targeting peptide, (AspSerSer)6, to synthesize F6-(DSS)₆-exo. F6

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11815285 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature