3D printed biodegradable hydrogel-based multichannel nerve conduits mimicking peripheral nerve fascicules.

ABSTRACT: Treating peripheral nerve injury (PNI) is a prevalent clinical challenge. The improper dispersion of regenerating axons makes it difficult to develop nerve guidance conduits (NGCs) for treating PNI. The multichannel NGCs, designed to mimic the fascicular structure of nerves, are proposed as an alternative to single hollow lumen NGCs. Hydrogel-based NGCs with microscale multichannels resembling actual nerve fascicles are fabricated using digital light processing as 3D printing. Gelatin methacryloyl (GelMA) and polyethylene glycol diacrylate (PEGDA), which are biodegradable and photocurable, are used as the printing solution. The addition of a food-grade dye to the printing solution can prevent overcuring by adjusting the optical path length of light and regulating the polymerization rate. T

SUBMITTER: Maeng WY 

PROVIDER: S-EPMC11815286 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature